Study title: Understanding the Systemic Impacts of Tuberculosis on Muscle through Biochemical and Radiological Assessment (The SIMBA Study)

Lead Researcher(s)

Edson Marambire, Angus de Wilton

Funder(s)

Elizabeth Blackwell Institute, University of Bristol

Partner(s)

University of Bristol, United Kingdom; London School of Hygiene and Tropical Medicine, University of Munich; University of Southampton, Research Center Borstel, Ministry of Health and Child Care, Zimbabwe, Harare City Health, National TB Program, Zimbabwe

Background

Pulmonary tuberculosis (TB of the lungs) can cause severe weight and muscle loss, (known as cachexia) leading to weakness and reduced strength. This can affect a person’s ability to walk, work, and carry out daily activities. Through this study, we aim to better understand how TB affects muscle health and recovery.

Study Aim(s)

To investigate the phenomenon of cachexia in pulmonary TB, including the long-term effects of TB on the musculoskeletal system.

Study Design

The SIMBA Study uses both a baseline cross-sectional approach and a prospective cohort design to study muscle health and recovery in people diagnosed with pulmonary TB in Zimbabwe. A total of 75 people with TB and 75 healthy controls will be enrolled in 2025. Participants will be assessed at the start, middle, and end of TB treatment. Each visit will include detailed measurements of muscle mass, strength, and power, as well as assessments of quality of life.

Study dates

March 2025 – December 2025